REGISTER HEREIt is an oral product, and is not considered an anabolic steroid. This is because its anabolic activity is known for being extremely weak — so weak, in fact, that it can be practically considered nonexistent. Proviron was initially developed nad Schering inmaking it one of the oldest steroids manufactured and marketed for medical use. Mesterolone is so old, in fact, that it shared its inception alongside Methyltestosterone deca homes talisay phase 2 map mesterolone and estrogen, and Testosterone Propionate inwhich were two of the first anabolic steroids put mesterolone and estrogen use in medicine as well. This is likely due to the fact that the former two anabolic steroids were demonstrated as being very strong anabolic agents, while the latter was not.
Proviron Mesterolone An Estrogen Antagonist | Free PLR Article Directory
Mesterolone has within our sport many purposes and its use and effect is debated and dicussed in many threads. What lots of bodybuilders don't realise is that the usage of all means is dependant, let me explain.
When you use a gram of testosterone you have a big chance that it will convert to a more aggressive and harsher compound, namely DHT. You most likely use un anti-estrogen like Arimidex. When on the other hand you use a gram of nandrolone, this will convert into a milder compound DHN by the same enzym 5-alpha-reductase.
PCT post cycle therapy is meant to avoid a crash after you stop using steroids. Bridging is the use of certain means some bodybuilders take between 2 cycles. There is no advantage of Arimidex or Femara over Proviron when it comes to control of estrogenic side effects. On the contrary, everything to estrogen largely suppressed, the only damage health rather than improve.
Arimidex anastrozole , Femara letrozole are very effective in suppressing estrogen and thus avoid these side effects. They are so effective, that too little estrogen is left to the health and growth of the body.
Therefore, these drugs are only suitable to cure certain types of cancer, NOT reduce aromatization of AAS where the disease is much less harmful than the side effects of the drug. Letrozole has also studies a negative effect on bone density 2. It suppresses estrogen E to a high degree:.
The selective estrogenic receptor modulators SERMs Nolvadex tamoxifen , exemestane, raloxifene in the contrary improve bone density and cholesterol unlike the anti-estrogens and aromatase blockers, mainly by selective binding to the ER.
Where anastrozole and letrozole will reduce your health, nolvadex will improve your health while the result is the same for preventing the negative estrogenic side effects 3. Proviron mesterolone during a lowdosed cycle should always be preferred over both Arimidex, Nolvadex or Letrozole. Mesterolone improved the libido in several studies, without testosterone suppression 4 , is a very good anti-depressant 5 , binds strongly to SHBG and allows more free testosterone to the AR in muscle tissue more AR-User Related muscle growth in test cures , because low mesterolone especially in low dose , the AR reaches gives little or no androgenic side effects such as enlarged prostate, body hair growth, MPB male pattern baldness , acne some very sensitive men will of course an increase in cures but rarely with proviron alone.
During a cycle proviron is always preferable over a non-steroidal aromatase blocker as the benefits for health and muscle growth are bigger. Nolvadex is most suitable for fighting local estrogenic side effects such as breast swelling with a positive effect on cholesterol as opposed to letrozole and anastrozole. Fluid retention can be fought with more selective agents without adverse effects on health aldosterone blockers. Those who want a worry-free cycle, can combine a small dose proviron in combination with a light dose of nolvadex.
This has minimal negative consequences for the health of the user. In order to understand this, one must initially review how and why testosterone is produced. Gonadotrophin releasing hormone GRH is the hormone that controls reproductive function. It is produced and released by a part of the brain called the hypothalamus and in turn controls the production and release of luteinising hormone LH and follicle stimulating hormone FSH called gonadotrophins from the adjacent pituitary gland.
LH acts with FSH to stimulate testosterone production, secreted by the interstitial cells of the testis and responsible for triggering the development of sperm and of many sexual characteristics such as the changes that occur during puberty in the penis and testicles.
Mesterolone is indicated in the treatment of testosterone deficiency or male infertility associated with malfunction of the hypothalamus, pituitary or testicles. The drug is administered orally and the initial recommended dosage is three or four 25mg tablets daily for several months, followed by maintenance therapy of two to three tablets mg daily.
It is not recommended in children and contraindicated when there is a history of previous or existing liver tumours, or in the presence of prostate cancer, as it may stimulate its growth. Mesterolone's molecular structure gives it special properties that set it apart from testosterone and all the drugs derived from testosterone that are used for this type of therapy, in that it is not broken down by the body metabolised to oestrogen.
This difference almost certainly accounts for the findings that, in its usual therapeutic dosage in normal men, mesterolone does not significantly depress the release of gonadotrophins from the pituitary.
Therefore sperm production spermatogenesis is unimpaired by mesterolone when compared with other drugs used in this area, which suppress and therefore replace the body's natural endogenous testosterone. In other words, Mesterolone supplements ones natural testosterone. Mesterolone administration produced no changes in steroids, thyroid hormones, gonadotropins nor PRL. Int J Gynaecol Obstet. Seminal analysis were assayed 3 times and serum follicle stimulating hormone FSH luteinizing hormone LH and plasma testosterone were assayed once before treatment and repeated at 3, 6, 9 and 12 months after the initiation of treatment.
There was no significant adverse effect on testosterone levels or on liver function. Those with severe oligospermia count less than 5 million do not seem to benefit from this therapy. We have assessed the gonadotropin, TSH and PRL responses to the non aromatizable androgens, mesterolone and fluoxymestrone, in 27 patients with primary testicular failure. Nine subjects received a further bolus of TRH at 30 mins. The latter were then given mesterolone mg daily for 6 weeks.
The remaining subjects received fluoxymesterone 5 mg daily for 4 weeks and 10 mg daily for 2 weeks. When compared to controls, the patients had normal circulating levels of testosterone, estradiol, PRL and thyroid hormones. Submitted by RonnyT on Mon, It suppresses estrogen E to a high degree: Updated later a few relevant scientific studies: August , 37 J Steroid Biochem Mol Biol. Oct , 87 1: January , 46 1: Login to post comments.