Page not availableAnabolic growth hormone side effects people turn to a substance called human growth hormone HGH growtg hopes that it will keep them feeling and looking youthful. But experts say that hope is unfounded. And worse, these products can be harmful. HGH, produced by the pituitary gland, spurs growth in children and adolescents. It also helps to regulate body composition, body fluids, muscle and bone hormonne, sugar and fat anabolic growth hormone side effectsand possibly heart function. Produced synthetically, HGH is the active ingredient in a number of prescription drugs and in other products available widely over the Internet. Synthetic human growth hormone was developed in and approved by the FDA for specific uses in children steroid nasal spray side effects eyes adults.
Growth Hormone: What Is It And What Does It Do - An Expert's View!
Since its inception, and first application as a bodybuilding super-substance GH has remained an anabolic that has attracted many conflicting opinions and has been shrouded in mystery.
In their quest for greater muscle size and the ripped, dry look that characterizes a top-level bodybuilding physique, competitors have, since the 's, as is generally thought, used a variety of supplemental substances, both naturally and pharmaceutically derived. After experiencing unprecedented muscle growth with anabolic steroids in the early '60s a time when these drugs were used in larger quantities as the level of bodybuilding competition increased , bodybuilding competitors knew they had found the critical factor necessary to take them several steps higher towards physical perfection, and iron warriors the world over have not looked back since.
With the 's ushering in a new era for competitive sporting success, with the emergence of lucrative contracts and entire careers based a upon athletic ability, a new compound found its way into the drug regimes of champions not adverse to pushing the boundaries: As a hormone critical for the health and well being of all humans, Growth Hormone is needed in precise amounts for the optimal functioning of a number of physiological processes and growth of body tissues, including muscle.
Generally this is achieved, resulting in growth and functioning within 'acceptable' and 'normal' parameters. However, an over or under production of GH can potentially cause serious health concerns. Excess GH, as occurs in those with Acromegaly, ultimately leads to an overgrowth of tissues and problems such insulin resistance and muscle weakness.
GH-secreting tumors, occurring in childhood, can also cause excessive GH production and resultant Pituitary Giantism, as witnessed with Andre the Giant , for example, who at 12 years old stood 6'3" and at his full height was 7'4". He ultimately died from this condition. As there can be problems with an over production of GH there can also be so with too little.
Genetic conditions and congenital malformations manifested through GH deficiency can cause a lack of growth in children. In both of these groups, carefully monitored GH supplementation restores the functions affected by GH deficiency. Benefits, in this context, generally include reduced fat mass, increased lean muscle tissue, increased bone density, improved lipid fat profile, reduced cardiovascular risk factors and improved mental health.
Bodybuilders being bodybuilders soon realized that if GH were introduced into their drug repertoire big muscles and shredded conditioning would result. And this is exactly what was experienced in those who began using this, until then, largely unknown anabolic agent. Competitors of the '70s, and especially the '80s began to present a more refined look with chiseled muscle development reminiscent of Classical Sculpture and resembling deeply etched rock. Those guys, one could reasonably postulate, were not adding additional cardio to their programs and eating more lean proteins.
Since GH had become a mainstay for serious bodybuilders worldwide, it has attracted its fair share of criticism: Those who use it, however, know just how effective it can be. Indeed, since its inception, and first application as a bodybuilding super-substance GH has remained an anabolic that has attracted many conflicting opinions and has been shrouded in mystery.
I sought some answers. One man who has, for many years, observed GH being used, and who is the first to say how effectively it builds muscle and reduces fat, but is also realistic as far as its application and efficacy in all who use it, is Ali Amini.
It is released into the blood-stream by the somatotrope cells of the anterior pituitary gland. Initially it was taken from human pituitary glands, however, in , biosynthetic GH replaced this earlier version. What of Growth Hormone's widespread use and its application amongst the sporting elite? But it is not as essential a part of contest prep or of an off-season cycle as most think.
In light of Ali's observations GH does not appear to be the magic bullet that many feel will give them bodybuilding success. However, if a bodybuilder were to solely use GH while excluding anabolic steroids from their program, what kind of effect would this have on their physique? But, though not a miracle drug, GH can work well for bodybuilders as shown in those who use it at optimal dosages. Surely if it is used by all professional bodybuilders it must have much merit. This results in bloating because of all the water retention caused by that dose.
So what is the optimal dose of GH one should take to attain its benefits? Needless to say, period taken and consistency is more important than the total amount, as taking a IU kit of GH over 50 days at 4 IU a day is more efficient than taking the same IU over a period of 25 days at 8 IU a day. As is clear from what Ali has said, GH used in conjunction with anabolic steroids is the most effective form of administration. It is known to work, but how? What exactly does GH do and what are its positive effects?
It is as powerful as testosterone in stimulating protein synthesis properties. Those who are GH deficient are often cited as proof positive that GH is an important building agent; that we all need it to function properly. Ali's take on GH deficiency? And how long does GH have to exert its anabolic effects? After that, blood concentrations of GH reach their peak between one and three hours after injection. So once the optimal dosage of GH and the potential benefits have been decided, how can it be administrated timing-wise?
IGF-1 production is regulated by factors other than GH, most notably nutritional and thyroid status. Some speculations recommend taking GH at any time because they say what I just mentioned is applicable for the GH produced by the pituitary and not that externally administrated. However, the body produces GH in those conditions because it is the best time for it, sequentially leading it to function at its maximum potential.
Therefore, using GH at a time when insulin is low using blood sugar as an indicator , post workout would be the best time to use it. However, if administrated in conjunction with insulin, GH should be taken immediately post workout with the insulin administered within a minute window after that.
Since within bodybuilding circles it is common knowledge that elite competitors take GH twice a day, and that timing is of the essence, if post workout is one of these optimal periods, when is the other? However, it would be even better to take it the second GH dose during the sleeping period, when, for example, waking up in middle of the night to go to the bathroom.
The liver can work with three to four IU of GH at a time and can do that twice a day with a reasonable gap of five to seven hours. Therefore, the best dose would be a total six to eight IU a day divided into two doses and having those five to seven hours apart. For example, a dose either three or four IU can be taken post training with another three to four IU dose before bed or during the night sleeping period.
Clearly, as with any anabolic agent, there is an optimal dosage, but it has not been clearly documented as to what would occur if one took too little or too much GH. If one took below the recommended IU of six to eight per day of GH, as Ali recommends, what effects, if any, could they experience?
If a bodybuilder took, for example, 2 IU, what effect would this have? However, taking less will definitely work and the gains will be noticed, just not at full potential the body's full capability of occupying GH and employing it.
Conversely, what would be likely to happen if that same person took well over the recommended amount? If they took, for example, 20 to 25 IU what could happen? But if you understand how GH works in the body and how the body utilizes it, it will become pretty obvious how, when and how much you should take.
Needless to say, trying to make GH use more constant for a longer period of time will result in more gains and make it much more cost efficient, as the legitimate form of it is still not cheap. That being said, GH does, like any other drug, hold dangers if used irresponsibly. So exactly how does GH compare to other anabolic drugs in terms of health problems if used excessively?
With GH, by comparison, you don't need any special form of detoxification post cycle, as the body doesn't become toxic from legitimate GH. As Ali says, insulin, a transport hormone, secreted from the pancreas to store nutrients in various body tissues, can be extremely dangerous if taken synthetically for bodybuilding purposes.
It is also understood that insulin and GH do not interact positively with one another to produce lean muscle gains. What is the deal here? That is just how the human body works. Therefore you need to supplement your body with the two hormones mentioned to compensate the shortage, edge out the gains and minimize the side effect of insulin.
Naturally, GH is produced best when insulin levels are low, and biologically that is the best time for GH to be produced and to begin working.
Depending on your insulin protocol, which we won't get into here because this is a discussion about GH, GH should be taken when insulin is low. And I advocate this protocol because this is the way the body works and all we can do is learn more about this and act accordingly.
You can say that the body is doing this in absence of an external source of GH and insulin and choose to take them both at the same time. But why risk the benefits and gains when there is no study to prove this? And what I am recommending is what is recommended by the body in the first place. As I said, GH can be taken post workout in an intramuscular manner to reach the system ASAP and then insulin can be introduced minutes after that. GH can be taken in a variety of ways, but what is the most effective method?
What do the pros do? But in the case of "GH in sports" it is different. The administrator is not a deficient patient; he is a person who wants GH to work in his body as soon as possible to get the most benefit from it, making the intramuscular IM method the best choice for administration in athletes as, in this fashion, it reaches the system much faster and starts its actions sooner than a sub-q injection.
It is often thought that the larger the competitor, the more GH they will need to realize any kind of benefit. It seems this is yet another myth. As is known, all drugs have their share of side effects. What can be expected as far as the deleterious effects of taking GH?
Can death result, as some think? These are the serious potential effects. Jaw and nose growth are the main, and most noticeable, signs of using GH over a longer period. No study has yet proved that GH causes cancer, even though a lot of speculation is made.
So no GH or, for that matter, any anabolic steroid is cancerous theoretically to date unless the person has been suffering from cancer before using any kind of anabolic; which, in some forms of cancer, the usage of anabolic drugs might worsen the case. As Ali suggested before, the intramuscular method of GH administration is the most popular, as this causes a faster cascade of Insulin-like Growth Factor 1 IGF-1 and faster growth as a result.
Why is this method best exactly? Why can't it be taken orally like some anabolic steroids? According to Ali this is "because it is a protein hormone and, as a result, has to be administered by injection as it is completely digested to its basic amino acids the amino acids it was made of when administered by mouth, which means it can't be differentiated from an oral amino acid supplement.
Thus, only injectable administration can allow GH to function at its full potential. With their eternal search for a bodybuilding edge, bodybuilders have turned to synthetic growth hormone to boost what nature provides for them naturally. But is it as effective as many are led to believe? The fact bodybuilders at the cutting edge use it to obtain rock hard definition and additional muscle size is testimony to its powerful nature, but according to Ali it is not a miracle substance and will not work as effectively as steroids for adding pure muscle mass.
However, in today's ultra competitive bodybuilding climate any edge appears to be worth pursuing and chemicals seem to be a firmly entrenched way in which to gain it.
So is GH use good or bad?