Food supplement appears to prevent weight gainScientists in the UK have developed a supplement that can reportedly switch off cravings for high-calorie foods, such a pizza and doughnuts, while leaving the healthy appetite unaffected. This is a small and very early trial, so we can't get test finale primo soccorso aziendale excited just yet. But the supplement, developed by researchers at Imperial College London, is based on a molecule produced by gut bacteria that tells the brain when you've eaten enough, and suppldment on from years suplpement work into the feedback pathway. The team had already shown that eating a type of fibre called inulin can increase the propionate dietary supplement of the molecule propionate in the intestine, which is made propiobate gut bacteria when you're full, and signals to the brain to stop eating. But they'd also shown that, by modifying inulin to contain propionate - propionate dietary supplement compound they've called inulin-propionate ester - they could trigger gut bacteria to produce as much as 2. To test propionate dietary supplement that affects appetite, in this latest research, the team gave 20 volunteers either a milkshake containing 10 grams of inulin propionate ester, or regular inulin on its own, which acted as the control. They supplemment had them lie in an MRI scanner while they were shown various pictures of low or high calorie propionate dietary supplement, such as salad and fish, or chocolate and cake.
Scientists have found a supplement that can switch off junk food cravings
Eating a type of food supplement, based on a molecule produced by bacteria in the gut, reduces cravings for high-calorie foods, study suggests. Scientists from Imperial College London and the University of Glasgow asked 20 volunteers to consume a milkshake that either contained an ingredient called inulin-propionate ester, or a type of fibre called inulin.
Previous studies have shown bacteria in the gut release a compound called propionate when they digest the fibre inulin, which can signal to the brain to reduce appetite. However the inulin-propionate ester supplement releases much more propionate in the intestines than inulin alone. After drinking the milkshakes, the participants in the current study underwent an MRI scan, where they were shown pictures of various low or high calorie foods such as salad, fish and vegetables or chocolate, cake and pizza.
The team found that when volunteers drank the milkshake containing inulin-propionate ester, they had less activity in areas of their brain linked to reward - but only when looking at the high calorie foods. These areas, called the caudate and the nucleus accumbens, found in the centre of the brain, have previously been linked to food cravings and the motivation to want a food.
The volunteers also had to rate how appealing they found the foods. The results showed when they drank the milkshake with the inulin-propionate ester supplement they rated the high calorie foods as less appealing.
In a second part of the study, which is published in July edition of the American Journal of Clinical Nutrition, the volunteers were given a bowl of pasta with tomato sauce, and asked to eat as much as they like.
When participants drank the inulin-propionate ester, they ate 10 per cent less pasta than when they drank the milkshake that contained inulin alone. In a previous research study by the same team, published in , they found that overweight volunteers who added the inulin-propionate ester supplement to their food every day, gained less weight over six months compared to volunteers who added only inulin to their meals. This study is filling in a missing bit of the jigsaw - and shows that this supplement can decrease activity in brain areas associated with food reward at the same time as reducing the amount of food they eat.
He added that eating enough fibre to naturally produce similar amounts of propionate would be difficult: To get the same increase from fibre alone, we would need to eat around 60g a day. At the moment, the UK average is 15g. Claire Byrne, a PhD researcher also from the Department of Medicine explained that using inulin-propionate ester as a food ingredient may help prevent weight gain: Dr Tony Goldstone, co-senior author of the study from the Department of Medicine added: These show that altering how the gut works can change not only appetite in general, but also change how the brain responds when they see high-calorie foods, and how appealing they find the foods to be.
This study illustrates very nicely that signals produced by the gut microbiota are important for appetite regulation and food choice. This study also sheds new light on how diet, the gut microbiome and health are inextricably linked adding to our understanding of how feeding our gut microbes with dietary fibre is important for healthy living.
Imperial Innovations, the College's technology transfer partner, has filed a patent on the underlying technology and is seeking commercial partners. Kate Wighton Communications and Public Affairs. Research , Strategy-share-the-wonder See more tags. Your comment may be published, displaying your name as you provide it, unless you request otherwise. Your contact details will never be published. Cravings for high-calorie foods may be switched off by new food supplement by Kate Wighton 01 July Our previous findings showed people who ate this ingredient gained less weight - but we did not know why.