Alopecia AreataAsk a Question Login Sign Alopecia steroid injections side effects. New Member 10 years on site 2 posts. Hi, I am 24 and I have alopecia areata. I had it when I was 16 and went through about a year of treatment. My hair grew back and I thought I was over this! Yet here I am today with it again. I received sids cortisone injection treatment in July and my hair started growing by the end of August.
Alopecia Areata - Causes & Symptoms. Baldness and hair loss | Patient
Alopecia areata AA is a type of autoimmune disease characterized by hair loss that has a variable presentation and course. Some patients exhibit spontaneous remission, while others progress to develop total loss of scalp and body hair. The current therapy for AA is not curative, but rather aimed at controlling or limiting the pathogenic process.
Their use was first described in , with the use of hydrocortisone. Steroids with low solubility are preferred for their slow absorption from the injection site, promoting maximum local action with minimal systemic effect. Immunosuppression is the main mechanism of action. Preparations used include triamcinolone acetonide, triamcinolone hexacetonide, and hydrocortisone acetate. Triamcinolone acetonide is the preferred intralesional product because it is less atrophogenic than triamcinolone hexacetonide.
The efficacy of ILCs injection is variable depending on the patient population treated. Although ILCs have been used in the treatment of AA for about 50 years, there are no published randomized controlled trials. Sterile saline is preferred over Xylocaine as a dilutent, because the latter stings more.
The device should be sterilized between patients. Treatments are repeated every four to six weeks. The decreased expression of thioredoxin reductase 1 in the outer root sheath may be the cause for glucocorticoid resistance in some AA patients. Re-injecting areas of denting, if avoided, is sufficient to allow the atrophy to revert.
The ultrasonic assessment of cutaneous atrophy by ILCs has revealed that the atrophy is transient and eventually normal thickness of the skin is regained. ILCs are most suitable for patchy, relatively stable hair loss, of limited extent. ILCs are still the preferred method of treatment for most patients.
National Center for Biotechnology Information , U. Journal List Int J Trichology v. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Open in a separate window. Atrophy can be prevented by avoiding injections that are too great in volume per injected site, too frequent or too superficial.
Footnotes Source of Support: Nil Conflict of Interest: Kalkoff KW, Macher E. Growing of hair in Alopecia Areata and maligna after intracutaneous hydrocortisone injection. Mandani S, Shapiro J. J Am Acad Dermatol. Shapiro J, Price VH. Treatment of severe Alopecia Areata with intralesional steroid injections. Bethesda, Maryland, October , Abell E, Munro DD. Interventions for Alopecia Areata. Cochrane Database Syst Rev.
Garg S, Messenger AG. Semin Cutan Med Surg. Porter D, Burton JL. A comparison of intra-lesional triamcinolone hexacetonide and triamcinolone acetonide in Alopecia Areata. Intralesional triamcinolone acetonide in Alopecia Areata amongst 62 Saudi Arabs. East Afr Med J. Glucocorticoid regulation of hair growth in Alopecia Areata. Effect of thioredoxin reductase 1 on glucocorticoid receptor activity in human outer root sheath cells.
Biochem Biophys Res Commun. Ultrasonic assessment of cutaneous atrophy caused by intradermal corticosteroids.
J Dermatol Surg Oncol. Ocular complications of topical, peri-ocular, and systemic corticosteroids. Anaphylaxis to intradermal triamcinolone acetonide.