Equate Allergy & Sinus Headache Side EffectsOne ingredient in this product side effects equate allergy medication acetaminophen. Taking too much acetaminophen may cause serious possibly fatal liver disease. Adults allerty not take more than milligrams 4 grams of acetaminophen a day. People with liver problems and children should take less acetaminophen. Ask your doctor or pharmacist how much acetaminophen is safe to take.
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Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:. All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may also report side effects at http: Cardiovascular side effects of acetaminophen have included two cases of hypotension.
Cardiovascular side effects of diphenhydramine have included hypotension, tachycardia , and palpitations. Cardiovascular side effects of phenylephrine have included palpitations, arrhythmias, and cardiovascular collapse with hypotension. Two cases hypotension have been reported following the administration of acetaminophen.
Both patients experienced significant decreases in blood pressure. One of the two patients required pressor agents to maintain adequate mean arterial pressures. Neither episode was associated with symptoms of anaphylaxis. Neither patient was rechallenged after resolution of the initial episode. Dermatologic side effects have included erythematous skin rashes. Acetaminophen associated bullous erythema and purpura fulminans have also been reported.
Acetaminophen has been associated with a risk of rare but potentially fatal serious skin reactions known as Stevens-Johnson syndrome SJS , toxic epidermal necrolysis TEN , and acute generalized exanthematous pustulosis AGEP.
One study has suggested that acetaminophen may precipitate acute biliary pain and cholestasis. The mechanism of this effect may be related to inhibition of prostaglandin and alterations in the regulation of the sphincter of Oddi.
Gastrointestinal side effects of acetaminophen have included rare cases of acute pancreatitis. Gastrointestinal side effects of diphenhydramine have included nausea and dry mouth.
Gastrointestinal side effects of phenylephrine have included nausea. Genitourinary side effects of diphenhydramine have included urinary retention and dysuria. Genitourinary side effects of phenylephrine have included dysuria. Hematologic side effects of acetaminophen have included rare cases of thrombocytopenia. Methemoglobinemia with resulting cyanosis has also been observed in the setting of acute overdose.
Hematologic side effects of diphenhydramine have rarely included hemolytic anemia , thrombocytopenia, and agranulocytosis. Alcoholic patients may develop hepatotoxicity after even modest doses of acetaminophen. However, hepatotoxicity has been reported following smaller doses. Glutathione concentrations may be repleted by the antidote N- acetylcysteine.
One case report has suggested that hypothermia may also be beneficial in decreasing liver damage during overdose. In a recent retrospective study of patients admitted for acetaminophen overdose , 6.
None of the patients died. A 19 year old female developed hepatotoxicity, reactive plasmacytosis and agranulocytosis followed by a leukemoid reaction after acute acetaminophen toxicity. Hepatic side effects of acetaminophen have included severe and sometimes fatal dose dependent hepatitis in alcoholic patients. Hepatotoxicity has been increased during fasting.
Several cases of hepatotoxicity from chronic acetaminophen therapy at therapeutic doses have also been reported despite a lack of risk factors for toxicity. Most commonly, hypersensitivity to diphenhydramine has manifested itself in patients receiving systemic drug after being sensitized to it by topical application. Sensitization with systemic administration has also been reported. Hypersensitivity side effects of acetaminophen have included rare reports of anaphylaxis and fixed drug eruptions.
Hypersensitivity side effects to diphenhydramine have included rash, pruritus and eczema. Photosensitivity reactions have also been reported.
The CNS depressant effect of diphenhydramine parallels its plasma concentrations. Patients should be warned against driving while taking diphenhydramine. Dystonic reactions have been accompanied by dizziness, mental confusion, rigidity, lip and tongue protrusion, trismus, torticollis , and swallowing difficulties and generally resolve spontaneously.
Toxic encephalopathy has been reported in a child with chicken pox treated generously with topical diphenhydramine. Delirium has been reported in elderly patients with mild dementia following a small oral dose of diphenhydramine. Nervous system side effects of diphenhydramine have included depression with drowsiness and sedation in nearly all patients treated. Motor skills may be impaired. Dystonic reactions have been reported after single doses of diphenhydramine.
Nervous system side effects of phenylephrine have included headache , dizziness, nervousness, restlessness, tremor, insomnia , convulsions, and central nervous system depression.
Renal side effects of acetaminophen have included acute tubular necrosis and interstitial nephritis. Adverse renal effects are most often observed after overdose, after chronic abuse often with multiple analgesics , or in association with acetaminophen-related hepatotoxicity.
Acute tubular necrosis usually occurs in conjunction with liver failure, but has been observed as an isolated finding in rare cases. A possible increase in the risk of renal cell carcinoma has been associated with chronic acetaminophen use as well. A recent case control study of patients with end-stage renal disease suggested that long term consumption of acetaminophen may significantly increase the risk of end-stage renal disease particularly in patients taking more than two pills per day.
Respiratory side effects of acetaminophen have included a case of eosinophilic pneumonia. Respiratory side effects of phenylephrine have included respiratory difficulty.
Psychiatric side effects of phenylephrine have included hallucinations, fear, and anxiety. General side effects of phenylephrine have included pallor and weakness. Tylenol Extra Strength PM acetaminophen-diphenhydramine. Lee WM "Medical progress: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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