Does Pulse Dosing of Methylprednisolone Have an Acute Effect on Serum Creatinine Concentrations?Intravenous supra-pharmacological doses of corticosteroids are used in various inflammatory and autoimmune conditions because pulse steroids solumedrol are cumulatively less toxic than sustained steroid treatment at lower quantitative dosage. Their action is supposed to be mediated through non-genomic actions within the cell. Common indications for use in children include steroid resistant and steroid dependent nephrotic syndrome, rapidly progressive glomerulonephritis, systemic vasculitis, systemic lupus erythematosus, acute renal allograft rejection, juvenile rheumatoid arthritis, juvenile dermatomyositis, pemphigus, optic neuritis, multiple sclerosis and acute disseminated encephalomyelitis. Methylprednisolone and dexamethasone show similar efficacy in most conditions. Therapy is associated with tren turistico granada horarios pulse steroids solumedrol effects including worsening of hypertension, infections, dyselectrolytemia and behavioral effects.
Does Pulse Dosing of Methylprednisolone Have an Acute Effect on Serum Creatinine Concentrations?
Use solution within 48 hours after mixing. Powder Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Management of severe ulcerative colitis: Same as day 2 except 1 tab at bedtime. This dose may be repeated every 4 to 6 hours for 48 hours.
Although adverse effects associated with high dose short-term corticoid therapy are uncommon, peptic ulceration may occur. Prophylactic antacid therapy may be indicated. In other indications initial dosage will vary from 10 to 40 mg of methylprednisolone depending on the clinical problem being treated.
The larger doses may be required for short-term management of severe, acute conditions. The initial dose usually should be given intravenously over a period of several minutes. Corticoid therapy is an adjunct to, and not replacement for conventional therapy. Dosage may be reduced for infants and children but should be governed more by the severity of the condition and response of the patient than by age or size.
It should not be less than 0. Dosage must be decreased or discontinued gradually when the drug has been administered for more than a few days. If a period of spontaneous remission occurs in a chronic condition, treatment should be discontinued. Routine laboratory studies, such as urinalysis, two-hour postprandial blood sugar, determination of blood pressure and body weight, and a chest X-ray should be made at regular intervals during prolonged therapy.
Upper GI X-rays are desirable in patients with an ulcer history or significant dyspepsia. A-Methapred may be administered by intravenous or intramuscular injection or by intravenous infusion, the preferred method for initial emergency use being intravenous injection.
To administer by intravenous or intramuscular injection, prepare solution as directed. The desired dose may be administered intravenously over a period of several minutes. To prepare solutions for intravenous infusion, first prepare the solution for injection as directed.
Multiple Sclerosis In treatment of acute exacerbations of multiple sclerosis, daily doses of mg of prednisolone for a week followed by 80 mg every other day for 1 month have been shown to be effective 4 mg of methylprednisolone is equivalent to 5 mg of prednisolone.
Directions for Reconstitution 1. Cleanse stopper with suitable germicide. Agitate to effect solution. Insert needle through target area of stopper until tip is just visible. Medical Calculators - A thru Z. Lab Values - A thru Z. This site complies with the HONcode standard for trustworthy health information: Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment.