Steroid atrophyWithin two weeks of starting Topical Steroid streoid, and probably within a few days, microscopic degenerative changes may be seen in the epidermis with a dianabol estrogen side effects of cell size and the number of cell layers. These skin thinning from steroid cream reversible may be rapidly reversible but with skin thinning from steroid cream reversible administration, dermal changes become apparent. There is inhibition of the mitotic activity of fibroblasts resulting in reduction of collagen and glycosaminoglycan synthesis but probably the earliest evidence of dermal atrophy is a reduction in the diameter of the fibrils and then the collagen bundles become atrophic and separated. The latter effects have been reported to be caused by the inhibition of collagenase by steroids. Elastin fibres in the upper layers of the dermis become thin and fragmented whereas those deeper down compact into a dense network. As a result of atrophic changes such as striaetelangiectasiaspurpura and ecchymosis develop.
skin thinning? - Inspire
Michelle Levy Skin Care Blog. I frequently have patients tell me that they are concerned about using cortisone creams because they have heard that they thin the skin.
While it is true that strong topical cortisones can thin the skin, in practice, this is very uncommon with milder creams, especially when they are used properly. Steroids are hormones that decrease inflammation in many ways, including by acting on the body's immune cells. Steroids in ointments or creams have been safely used in the treatment of skin diseases since the s. There are dozens of topical steroids cortisones on the market today in Canada and the US. These medications are divided into seven classes, mainly based on their chemical structure.
Cortisones from other classes fall somewhere in-between. Apart from its chemical structure, factors that influence the potency of a topical steroid include the type of vehicle the medication is in greasy ointments are more potent than creams , the concentration of the active ingredient, and the type of skin to which it is being applied.
Thin-skinned areas such as the face or eyelids will absorb a medication much more readily than thick-skinned sites such as the back or palms.
For this reason, dermatologists will typically choose a mild cortisone for the face and a stronger product for the body. Skin thinning is rarely seen with the proper use of mild or even mid-strength topical steroids. Cortisones used in these areas undergo "occlusion" and become much more potent. Permanent stretch marks can develop with the use of a mid or high potency steroid in these areas after relatively brief periods of time.
The side effects of cortisone creams can best be avoided by using these creams intermittently , and by using the right product on the right part of the body. There are various measures that can then be used to maintain the improvement achieved by the cream; speak with your dermatologist about how to use your prescription medicine properly.
When used properly, most topical cortisones have an excellent safety profile. Skin thinning is uncommon with short-term or intermittent use, and is often reversible when it occurs. Hydrocortisone is the weakest of the topical steroids and it would be very unlikely to cause skin thinning when used properly. Mid and high potency topical steroids should only be used under a doctor's supervision, and instructions for use should be followed carefully.
Applying a strong topical steroid too liberally or too frequently, or using it in areas for which it was not intended can indeed result in unwanted side effects. Contact Us Sheppard Ave. Why Visit a Dermatologist? Michelle Levy Dermatologist Toronto Dr. Michelle Levy writes about common skin conditions. What is the Bottom Line? Are Self-Tanning Creams Safe? How do I choose an over-the-counter Michelle Levy Toronto Dermatologist Dr.